A0PZT1

PR
Gene name
pbpA (NT01CX_1810)
Protein name
Penicillin-binding protein 1A
Names
PBP1a
Species
Clostridium novyi (strain NT)
KEGG Pathway
cno:NT01CX_1810
EC number
2.4.1.129: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

752-863 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0PZT1

Entry ID Method Resolution Chain Position Source
AF-A0PZT1-F1 Predicted AlphaFoldDB

No variants for A0PZT1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0PZT1

No associated diseases with A0PZT1

2 regional properties for A0PZT1

Type Name Position InterPro Accession
domain Glycosyl transferase, family 51 78 - 267 IPR001264
domain Penicillin-binding protein, transpeptidase 393 - 673 IPR001460

Functions

Description
EC Number 2.4.1.129 Hexosyltransferases
Subcellular Localization
  • Cell membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
penicillin binding Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system.
peptidoglycan glycosyltransferase activity Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.
serine-type D-Ala-D-Ala carboxypeptidase activity Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine.

5 GO annotations of biological process

Name Definition
cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
regulation of cell shape Any process that modulates the surface configuration of a cell.
response to antibiotic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTENRDNKTS QSEKTTQKKK KKKFKAFKII LITFITLIVI SLVTAIGITL AIIKTSPDIN
70 80 90 100 110 120
INEIIAASDA SKIYDDKGEL VDSIITSKKK ILVKYDEVPE NLINAFVSIE DERFFKHSGI
130 140 150 160 170 180
DVKRIAGAFL IDMKNIVSGK PALQGASTIT QQLIKNTVFE THGNSLNDKL RRKVQEWYLA
190 200 210 220 230 240
PKLEKEVGKK SIMEAYLNTI YLGGRAIGVG AAADQYFNVS IDKLDLVQCA FIAGLPQSPS
250 260 270 280 290 300
VYYPYSRTSK KDPSKYINRT KTVLAKMKEN GYISQNEYIS ALAELDTSKS TVTNDESIQT
310 320 330 340 350 360
LGQYTIHKPT NIDEKYNFEW FTRPAIERVK KDLKDIYNYS DDEIEKLLVN GNLKIYTTMN
370 380 390 400 410 420
KDLQVSTQEI IDNDEKLNSL SSSKNNLVEP QASAVLTDYH TGEVKVIIGG RGTQPALAYN
430 440 450 460 470 480
RATNAKVAAG SSIKPLTVYS AAIDSKLATA ATVLEDSPLP EAMSKKYSAP GTNWQPKNAN
490 500 510 520 530 540
GVYSGYLGLR DALKNSVNVY AVKLEDKIGL NTGVKYGEKF GLTFDNVDKN SMAAIALGEL
550 560 570 580 590 600
NRGTNTFTMA NAYGVFGNNG MYSNPRLYTK VLDRNGNVLL ETKTQATQVI SPEAAYIMYD
610 620 630 640 650 660
LLKGPVKEGT ATRIQHTYHS DIPIAGKTGS STKFKNLWFC GLTPYYSGAV WIENKYGQSI
670 680 690 700 710 720
YSSDAAALFG KIMNRAVENL PEKEIEMPEG IIKAEVDRVS GLLPTDLSYK DPRGSQVYTE
730 740 750 760 770 780
LFIKGTVPTE QDNIHVSTKV NKYNGRVSGS YTPSFLTESK VFIKRQSDSE VPLDDDMYVL
790 800 810 820 830 840
PDKDKKSSNK SKHNHNNDAK HDNTNNSEDA TNEASTEPSP NTDTVPEDST NNLDPTKNTE
850 860
KKPSDKKNKK HVIKPIIRPK KHF