A0PZP4

PR
Gene name
mutS2
Protein name
Endonuclease MutS2
Names
Species
Clostridium novyi (strain NT)
KEGG Pathway
cno:NT01CX_1773
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

485-560 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0PZP4

Entry ID Method Resolution Chain Position Source
AF-A0PZP4-F1 Predicted AlphaFoldDB

No variants for A0PZP4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0PZP4

No associated diseases with A0PZP4

4 regional properties for A0PZP4

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 325 - 510 IPR000432
domain Smr domain 707 - 785 IPR002625
domain DNA mismatch repair protein MutS, core 9 - 312 IPR007696
domain MutS2 and Smr-associated SH3 domain 640 - 681 IPR046893

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

2 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
negative regulation of DNA recombination Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNEKSLRVLE FNKIKDELKK YTQTSAAKDL IERLHPYESA YEVREHLMET EEAFKISIKK
70 80 90 100 110 120
GDAPFSGLYD IREAISKAQR RFTLFPSELL RVANLLRASR RFKGYVKSDD LSEKYEVLES
130 140 150 160 170 180
ITEGLVPLNG LEEEISKCII GEEEISDRAS TTLFNIRRSL KDKTSSIKAR VNSLIRTYSS
190 200 210 220 230 240
HLQENIYTVR GERYVLPVKV EHKGAVPGLV HDQSASGATL FIEPMSLVDL NNEIKELRLK
250 260 270 280 290 300
EKAEIDRILA FLSGKVYENV DVIKVDADIL WELDFIFAKA KYAQKLGAIM PIISEDGHFN
310 320 330 340 350 360
IINAKHPLID PKKVVENNIY LRDGITSVVI TGPNTGGKTV TLKTVGLLHI MAMSGLMITA
370 380 390 400 410 420
SQGSTISFFK EVFADIGDEQ SIEQSLSTFS SHMTNIVNII DSADENSLVL FDELGAGTDP
430 440 450 460 470 480
TEGAALAVSI LENLRKRKTK VIATTHYSEL KAYALKVDNV ENASVEFDVE TLRPTYRLLI
490 500 510 520 530 540
GVPGKSNAFE ISKRLGLPDY IIEDAREGIS EETLKFEDLI QSLQHKNIKA QEHARKAESA
550 560 570 580 590 600
KEEAVKLKEK YESKLDKFQD IREKAILNAQ KEAKEIIKEA KEEADKILKD IRELERMGYS
610 620 630 640 650 660
SDVRKLLEEN RKKLKDKLEK TESKLNQPKE VGEAVTNVSE GDELYLPKFE TKVMVLTNPD
670 680 690 700 710 720
NKGDVQVQAG IMKIKVNIKD LRKTKETKIE KRQRKKKQMS LNLKSVATSV DLRGMDSEEA
730 740 750 760 770 780
TYTADKYLDD ACMSGLSEVT IIHGKGTGVL RTAINDMLKR HPHVKSYRLG NYGEGGNGVT
VVELK