A0PQ00

PR
Gene name
ppk
Protein name
Polyphosphate kinase
Names
ATP-polyphosphate phosphotransferase, Polyphosphoric acid kinase
Species
Mycobacterium ulcerans (strain Agy99)
KEGG Pathway
mul:MUL_1972
EC number
2.7.4.1: Phosphotransferases with a phosphate group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0PQ00

Entry ID Method Resolution Chain Position Source
AF-A0PQ00-F1 Predicted AlphaFoldDB

No variants for A0PQ00

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0PQ00

No associated diseases with A0PQ00

4 regional properties for A0PQ00

Type Name Position InterPro Accession
domain Polyphosphate kinase middle domain 168 - 372 IPR024953
domain Polyphosphate kinase N-terminal domain 53 - 158 IPR025198
domain Polyphosphate kinase C-terminal domain 2 555 - 723 IPR025200
domain Polyphosphate kinase, C-terminal domain 1 382 - 548 IPR041108

Functions

Description
EC Number 2.7.4.1 Phosphotransferases with a phosphate group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
polyphosphate kinase complex A protein complex that possesses polyphosphate kinase activity.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
polyphosphate kinase activity Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1).

2 GO annotations of biological process

Name Definition
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
polyphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIGNDRWVTE IETGPVTEAR PDTNAREPGD RTPAAPPAAT PAATTDQLPE DRYLNRELSW
70 80 90 100 110 120
LEFNARVLAL AADDSMPLLE RAKFLAVFAS NLDEFYMVRV AGLKRRDQMG LSALSADGLT
130 140 150 160 170 180
PREQLGRIGE QTQHIASRHA RVFRDSVLPA LGEEGIYVVT WADLDQAERE QLSTYFHEQV
190 200 210 220 230 240
FPVLTPLAVD PAHPFPFVSG LSLNLAVTVR QPEDGGQHFA RVKVPDNVDR FVELGGTDTD
250 260 270 280 290 300
GAEGAAVHRF LPLEELIAAF LPVLFPGMEI VEHHAFRITR NADFEVEEDR DEDLLQALER
310 320 330 340 350 360
ELARRRFGSP VRLEVADDMT EGMLELLLRE LDVHPGDVIE VPGLLDLSSL WQIYGLDRPA
370 380 390 400 410 420
LKDRTFVPAT HPAFAERETP KSIFATLREG DVLVHHPYYS FSTSVQRFIE QAAADPNVLA
430 440 450 460 470 480
IKQTLYRTSG DSPIVRALID AAEAGKQVVA LVEVKARFDE QANIRWARAL EQAGVHVAYG
490 500 510 520 530 540
IVGLKTHCKT ALVVRREGPV IRRYCHIGTG NYNSKTARLY EDVGLLTAAP DIGADLTDLF
550 560 570 580 590 600
NSLTGYSRKL SYRNLLVAPH GIRAGIIERV EREVAAHLEH GPQAGKGHIR LKMNALVDEQ
610 620 630 640 650 660
VTDALYRASQ VGVRIEVVVR GICALRPGAE GFSENITARS ILGRFLEHSR ILHFRAIDEF
670 680 690 700 710 720
WIGSADMMHR NLDRRVEVMA QVKDPRLTAQ LDDLFESALD PATRCWELGP DGQWTASPQE
730
GRTVRDHQVS LMERHRSP