A0NEF7

PR
Gene name
AGAP005651
Protein name
Cytoplasmic tRNA 2-thiolation protein 2
Names
Species
Anopheles gambiae (African malaria mosquito)
KEGG Pathway
aga:AgaP_AGAP005651
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

337-417 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0NEF7

Entry ID Method Resolution Chain Position Source
AF-A0NEF7-F1 Predicted AlphaFoldDB

No variants for A0NEF7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0NEF7

No associated diseases with A0NEF7

3 regional properties for A0NEF7

Type Name Position InterPro Accession
domain Activin types I and II receptor domain 28 - 111 IPR000472
domain Protein kinase domain 190 - 480 IPR000719
active_site Serine/threonine-protein kinase, active site 317 - 329 IPR008271

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
nucleotidyltransferase activity Catalysis of the transfer of a nucleotidyl group to a reactant.
sulfurtransferase activity Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor).
tRNA binding Binding to a transfer RNA.

4 GO annotations of biological process

Name Definition
protein urmylation Covalent attachment of the ubiquitin-like protein URM1 to another protein.
tRNA thio-modification The addition a sulfur atom to a nucleotide in a tRNA molecule.
tRNA wobble position uridine thiolation The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
tRNA wobble uridine modification The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MCSIVEDDFG DEGGAHAMKE DTPQPELGGN ELCRKCNTEQ AVLKLNQKEP QCRVCFLNYV
70 80 90 100 110 120
RHKFRASLGS TKIVRRGSRV LIILTGEPAN VTLLDMVRFG LEQDAFKQLR IVPVLLYVDD
130 140 150 160 170 180
DFVGNTSEAR LQQLAERLQV FKQFESFPAY YTVCGSSRHV ALTFDGAFSP AGFEQDEARL
190 200 210 220 230 240
LQVLDAVRSV SSKQDLLEQV RKQTYRQIGH ALQCAYVFLS DIGVDLAKTL LSNVALGRGC
250 260 270 280 290 300
SLAQDVAFCD DRYNTVKLVR PIRDLNPDEV SNYLQYSEQP LLSYSPAKHF EDKPSLQNLT
310 320 330 340 350 360
AKFIDNLMQS FPSTVSTVYR TGDKLDAPKA ARNECCRFCG AALDYRGSKT LFATEYSRLV
370 380 390 400 410
SSRINAACSH EDILLKSKQM ELDAERAVNG EDDQGEERVL MKQLCHGCRN IFEDLNK