A0LYC0

PR
Gene name
pnp
Protein name
Polyribonucleotide nucleotidyltransferase
Names
Polynucleotide phosphorylase, PNPase
Species
Gramella forsetii (strain KT0803)
KEGG Pathway
gfo:GFO_0380
EC number
2.7.7.8: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

670-750 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0LYC0

Entry ID Method Resolution Chain Position Source
AF-A0LYC0-F1 Predicted AlphaFoldDB

No variants for A0LYC0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0LYC0

No associated diseases with A0LYC0

8 regional properties for A0LYC0

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 23 - 152 IPR001247-1
domain Exoribonuclease, phosphorolytic domain 1 333 - 465 IPR001247-2
domain S1 domain 627 - 700 IPR003029
domain K Homology domain 560 - 625 IPR004087
domain K Homology domain, type 1 565 - 622 IPR004088
domain Exoribonuclease, phosphorolytic domain 2 155 - 218 IPR015847
domain Polyribonucleotide nucleotidyltransferase, RNA-binding domain 250 - 329 IPR015848
domain RNA-binding domain, S1 628 - 700 IPR022967

Functions

Description
EC Number 2.7.7.8 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIPKTFKEVI DLGDGREISI ETGKLAKQAH GSVVVQSGKC MLLCTVVSNY EQKDLPFLPL
70 80 90 100 110 120
TVDYREKFAA AGRYPGGFFK REARPSDGEV LTMRLVDRVL RPLFPKDYSA ETQVMIQLMS
130 140 150 160 170 180
HDDEVMPEAM AGLAASAAIQ LSDFPFECAI SEARVGRVNG EFIINPTRAQ LAESDIEMMI
190 200 210 220 230 240
GASADSVMMV EGEMDEISEE DMVEAIKFAH EAIKVQIEAQ HRLADAFGRK EVREYEDAPE
250 260 270 280 290 300
NEDLVKKVHD MAYDKVYAVA KAGSSKKERT DAFASIKEEV KASFSEEELE EYGDLVSDYY
310 320 330 340 350 360
RKAEKAAVRD LTLNEGIRLD GRKTDEVRDI WCEVDYLPSV HGSSIFTRGE TQALATVTLG
370 380 390 400 410 420
TSRDANQIDM PSHEGEERFY LHYNFPPFCT GEARPIRGTS RREVGHGNLA QRALKGMIPE
430 440 450 460 470 480
ECPYTVRVVS EVLESNGSSS MATVCAGTMA LMDAGVQMKK PVSGIAMGLI SDGDSGKYAV
490 500 510 520 530 540
LSDILGDEDH LGDMDFKVTG TADGITACQM DIKVKGLSYE ILVNALKQAR DGRLHILEKL
550 560 570 580 590 600
TDTIAQPNAD VKAYAPKMIT RRIPNEFIGA LIGPGGKVIQ ELQKETGTTI VINEDPVTEE
610 620 630 640 650 660
GIIEILGTEQ EGIDKVIAKI ESITFKPEKG SVYEVKVIKV LDFGAVVEYM DAPGNEVLLH
670 680 690 700 710 720
ISELAWERTN DVNDVLKLGD VLDVKYFGLD PKTRKDKVSR KALMEKPEGY KERAPRDRDD
730 740
KRGSRDNNRG RDNRGRDNRR DDRKPRENKD