A0LE14

PR
Gene name
pnp
Protein name
Polyribonucleotide nucleotidyltransferase
Names
Polynucleotide phosphorylase, PNPase
Species
Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)
KEGG Pathway
mgm:Mmc1_3722
EC number
2.7.7.8: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

327-396 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0LE14

Entry ID Method Resolution Chain Position Source
AF-A0LE14-F1 Predicted AlphaFoldDB

No variants for A0LE14

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0LE14

No associated diseases with A0LE14

9 regional properties for A0LE14

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 13 - 142 IPR001247-1
domain Exoribonuclease, phosphorolytic domain 1 326 - 459 IPR001247-2
domain S1 domain 622 - 693 IPR003029
domain K Homology domain 555 - 620 IPR004087
domain K Homology domain, type 1 560 - 616 IPR004088
domain Exoribonuclease, phosphorolytic domain 2 145 - 208 IPR015847-1
domain Exoribonuclease, phosphorolytic domain 2 462 - 532 IPR015847-2
domain Polyribonucleotide nucleotidyltransferase, RNA-binding domain 239 - 323 IPR015848
domain RNA-binding domain, S1 623 - 693 IPR022967

Functions

Description
EC Number 2.7.7.8 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFNIHTKSVQ FGEKTITLET GRVARQANGA VMVTYGDTVV LVTAVAETSM RAGQDFFPLS
70 80 90 100 110 120
VHYQEKFWAA GKIPGGFIKR ETRPSEREVL TSRLIDRPIR PLFPKGFMNE TQVVAQVLSY
130 140 150 160 170 180
DPDYPSDIAA LIGCSAALAL SGVPFEGPIG GARVGFIDGK PVLNPTVDQL AASRLDLVVA
190 200 210 220 230 240
GTRSAVTMVE SEVDFLSEDE MLDCVMFAHE SFQPVITAIE ELVAEAGKPR WVVEPVQVNE
250 260 270 280 290 300
ALLAEMNDKF AAQVTEAYAI PEKMARYEAV AQVKAAAMEA LGTIEVDGQS VKRSEEVASL
310 320 330 340 350 360
FKKIESRTLR QNVLQGKRVD GRGLTDIRPI ACEVSILPRV HGTALFTRGE TQAIATVTLG
370 380 390 400 410 420
TSRDEQIVET LSGEYRDRFY LNYTFPPYCV GETGRMGAPG RREIGHGKLA TRALTAIVPS
430 440 450 460 470 480
AEVFPYTLRI TSEITESNGS SSMATVCGAV LAMQDAGVPI KAPVAGIAMG LVKEGDAYAV
490 500 510 520 530 540
LSDILGDEDH LGDMDFKVAG NADGITALQM DIKITGITRE IMAKALEQAR AGRLHILGEM
550 560 570 580 590 600
GKAMTTHRAE MSAYAPRIHT MKIHPDKIRE VIGSGGKVIR SITEETGCAI DIEDDGTIRI
610 620 630 640 650 660
ASSDQASAEQ AVKIIKSIVA EVEKGQVYEG KVVRITDFGA FVNILPNKDG LVHISQLANR
670 680 690 700
RVQNVTDVVK EGDVVTVKVL DVDRQGRVKL TMKEMEEGAA E