A0L8S1

PR
Gene name
metG
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)
KEGG Pathway
mgm:Mmc1_1856
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

507-602 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0L8S1

Entry ID Method Resolution Chain Position Source
AF-A0L8S1-F1 Predicted AlphaFoldDB

No variants for A0L8S1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0L8S1

No associated diseases with A0L8S1

8 regional properties for A0L8S1

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 11 - 22 IPR001412
domain tRNA-binding domain 583 - 686 IPR002547
domain Methionyl-tRNA synthetase, beta subunit, C-terminal 557 - 686 IPR004495
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 414 - 500 IPR013155
domain Methionyl/Leucyl tRNA synthetase 4 - 391 IPR015413
domain Methioninyl-tRNA synthetase core domain 3 - 358 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 379 - 390 IPR033911-2
domain Methionyl-tRNA synthetase, anticodon-binding domain 372 - 502 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRRILVTSAL PYANGHIHLG HLVEYIQTDI WVRFHKLRGE ECIYMCADDT HGTPIMLRAQ
70 80 90 100 110 120
KEGITPEQLV NQMHKEHAQD FAAFFVQFDE YYTTNSEENR LLSEEIYLKN RDGGHIEVDT
130 140 150 160 170 180
IQQAYCEHDA MFLPDRFIRG TCPHCGAVDQ YGDSCEVCSA TYRPTELKEA KCAVCGSQPV
190 200 210 220 230 240
EKSSEHYFFK LQDFSDYLKE WIQSGTLQPE MAAKLNEWFE QGLKHWDISR DGPYFGFEIP
250 260 270 280 290 300
DAPGKYFYVW LDAPTGYMAT TWHHCKKQGI NFDDYWRRDD KAEVYHFIGK DILYFHTLFW
310 320 330 340 350 360
PAMLHGSGFR TPTAVFAHGF LTVNGQKMSK SRGTFINARQ YSAFLNPEYL RYYYAAKLTS
370 380 390 400 410 420
RVDDLDLNLD DFVQRVNSDL VGKVVNLASR TAGFIVKRFE GQLCADYPED DGLFQQFHQA
430 440 450 460 470 480
GEEIAALYEK REFAKAMQAI MRLADSANQY VENHAPWVLA KDPLQSQRLQ QVCSVTLNLF
490 500 510 520 530 540
RTLMIFLKPV LPYMSNQVEQ LFNAPQPFVW QDTAAPLQGV TINAFKHLMS RVEKEKVDAM
550 560 570 580 590 600
VEAAREEAPS PTPQPKQQTK EKEEKNKKSA DKDALAASID FDTFMQVDLR VARIADAHEV
610 620 630 640 650 660
EGADKLLQLT LDLGETLGTR TVFAGIKSSY SAEQLKGRLT VVVANLAPRK MKFGISEGMV
670 680
LAAGPGGTDI HILSPDSGAQ PGQRIK