A0KQJ4

PR
Gene name
cysG3
Protein name
Siroheme synthase 3
Names
Species
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)
KEGG Pathway
aha:AHA_4121
EC number
1.3.1.76: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

166-237 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0KQJ4

Entry ID Method Resolution Chain Position Source
AF-A0KQJ4-F1 Predicted AlphaFoldDB

No variants for A0KQJ4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0KQJ4

No associated diseases with A0KQJ4

7 regional properties for A0KQJ4

Type Name Position InterPro Accession
domain Tetrapyrrole methylase 218 - 427 IPR000878
conserved_site Uroporphiryn-III C-methyltransferase, conserved site 221 - 235 IPR003043-1
conserved_site Uroporphiryn-III C-methyltransferase, conserved site 296 - 329 IPR003043-2
domain Uroporphyrin-III C-methyltransferase 216 - 448 IPR006366
domain Sirohaem synthase, N-terminal 4 - 203 IPR006367
domain Sirohaem synthase, dimerisation domain 150 - 207 IPR019478
domain Siroheme synthase, central domain 119 - 145 IPR028281

Functions

Description
EC Number 1.3.1.76 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
precorrin-2 dehydrogenase activity Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin.
sirohydrochlorin ferrochelatase activity Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin.
uroporphyrin-III C-methyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2.

3 GO annotations of biological process

Name Definition
cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
methylation The process in which a methyl group is covalently attached to a molecule.
siroheme biosynthetic process The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDYLPIFCRL DNKPVLLVGG GEVAERKARL LLDAGAQLTV VAPELDPELA ELAANGSIEW
70 80 90 100 110 120
LAGEFAPQQL TGKWLVVAAT DRREVNALVY QSANQARIFA NVVDDPKRSS FIMPSIIDRS
130 140 150 160 170 180
PLMVAISSGG KAPVLARLLR EKLEALLPQH LGAVAAFAGS LRERVKARFA SMGERRRFWE
190 200 210 220 230 240
RLLGADRLGQ ALARGDSASA NQLADSLFAD ESQSGGEVVL VGAGPGDPGL LTLHALRQMQ
250 260 270 280 290 300
QADVVVYDRL VSDEVMALVR RDARRIFVGK QAGNHCVPQE GINQLLLDEA KKGQRVVRLK
310 320 330 340 350 360
GGDPFIFGRG GEELETLVGS GIGFQVVPGI TAASGCAAYA GIPLTHRDHA QSVRFVTAHG
370 380 390 400 410 420
KGGAQDLDWP LLAKDKQTLV FYMGLSSCTT IREQLLTHGK AGDTPVALIE RGTQPSQRVI
430 440 450 460
RGTLAQLPEL ALGVESPALI MVGSVVTLAD QLAWFGQGGA ADAALASA