A0KPG5

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)
KEGG Pathway
aha:AHA_3718
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

779-854 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0KPG5

Entry ID Method Resolution Chain Position Source
AF-A0KPG5-F1 Predicted AlphaFoldDB

No variants for A0KPG5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0KPG5

No associated diseases with A0KPG5

5 regional properties for A0KPG5

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 618 - 808 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 20 - 131 IPR007695
domain DNA mismatch repair protein MutS, core 281 - 602 IPR007696
domain DNA mismatch repair protein MutS, connector domain 140 - 265 IPR007860
domain DNA mismatch repair protein MutS, clamp 439 - 529 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTAQHQATGT APGANLSAHT PMMQQYLTLK AENPEILLFY RMGDFYELFY DDARKASQLL
70 80 90 100 110 120
DISLTKRGQS AGSPIPMAGV PYHAIEGYLA KLVQLGESAA ICEQVGDPAT SKGPVERKVI
130 140 150 160 170 180
RIITPGTVSD EALLSERQDN LIAAVYHDGR RFGYGTMDIG SGRFFINQFE KEETLLAELQ
190 200 210 220 230 240
RTNPAELLYP ESFTFLHHVE GRRGLRRRPE WEFELGTARK LLCQQFGTQD LVGFGVEQSE
250 260 270 280 290 300
TALCAAGCLM QYVKDTQRTA LPHIRSVRLE QPDHAVIMDA ATRRNLELTQ NLAGGHDNTL
310 320 330 340 350 360
SAVLDCTATP MGSRLLKRWI HQPIRDQVIL KGRQSTIKEL IEQNLYDELG GLLRQVGDVE
370 380 390 400 410 420
RVLARLALRS ARPRDLTRLR QAFAQLPELQ RLLAESEHEA VQQLRERAST FPELLDLLER
430 440 450 460 470 480
AVMEVPPVLI RDGGVIRDGF NQELDELRDL ANGATASLAR IEERERLLTG INTLKVGYNK
490 500 510 520 530 540
VHGFYIEVSR ANSHLVPAHY IRRQTLKNNE RYIIDELKKY EDKVLTAQAQ ALALEKRLYE
550 560 570 580 590 600
ELLDALLPHL GDLQESAAAL AELDVLANLA ERAETLDYRC PTLIDEDQIL IEAGRHPVVE
610 620 630 640 650 660
QVMTDPFIAN PINLQRSRRM LIITGPNMGG KSTYMRQTAL IVLLAHIGAF VPADSARIGP
670 680 690 700 710 720
IDRIFTRIGA SDDLASGRST FMVEMTETAN ILNNATARSL VLMDEIGRGT STYDGLSLAW
730 740 750 760 770 780
ACAEQLASKI GAYTLFATHY FELTRLPELM EGLANVHLDA VEHGDTIAFM HAVQEGAASR
790 800 810 820 830 840
SYGLQVAALA GVPKSVIQQA RHKLHELESA TPVAAGESRP APVAMAPQSH PVVDELEAVR
850
PDELTPRQAL DLLYRLKQML