A0KMM4

PR
Gene name
aceK
Protein name
Isocitrate dehydrogenase kinase/phosphatase
Names
IDH kinase/phosphatase, IDHK/P
Species
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)
KEGG Pathway
aha:AHA_3021
EC number
2.7.11.5: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

95-166 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0KMM4

Entry ID Method Resolution Chain Position Source
AF-A0KMM4-F1 Predicted AlphaFoldDB

No variants for A0KMM4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0KMM4

No associated diseases with A0KMM4

2 regional properties for A0KMM4

Type Name Position InterPro Accession
domain Isocitrate dehydrogenase kinase/phosphatase (AceK), regulatory domain 10 - 309 IPR046854
domain Isocitrate dehydrogenase kinase/phosphatase (AceK), kinase domain 310 - 564 IPR046855

Functions

Description
EC Number 2.7.11.5 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
[isocitrate dehydrogenase (NADP+)] kinase activity Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQQPLEQAVA ETILQRFESF YSRFLEITQG SKSRFENSDW LGVQLAGRER IRLYDHHVGA
70 80 90 100 110 120
TTALIKQMMG ATLPSQALLK QVKGAFSDLL PKCENFEVAE SFFNSVYRRI FRHRNIRDEN
130 140 150 160 170 180
LYIHPFRSRG EHPDLSALLR IYRTDLAHLP QTLSQLLGDY SFTLPYEDKQ RDIVDIQRHL
190 200 210 220 230 240
AENGPAILHD EPFAIELLKE VFYRNKGAYL VGLIRVKGQV FPFILPLLST GQSIYVDTVI
250 260 270 280 290 300
FEPELASIVF GFARAYFMVY APMPALFVLF LRQIMPHKPD YEIYNAIGCQ KHGKTELYRH
310 320 330 340 350 360
YQQHLAQSRE QFVIAPGIKG MVMSVFTLPS YDVVFKVIKD EFTPPKDVSH EQVKAKYRLV
370 380 390 400 410 420
KQHDRVGRMA DTQEFTNFEF PLDRISPELL AELKTVAPSA LTLTDDKLVI KHLYTERKMI
430 440 450 460 470 480
PLNLYLDKAD EQQTRLALEE YGNAIKQLAA ANIFPGDMLF KNFGVTRHGR VVFYDYDEIC
490 500 510 520 530 540
YMTECNFRQI PPPRYPEDEW SAEPWYSVAP NDIFPEEFAT FLLQKPQVRD IMMQLHKELF
550 560 570
DANYWKMLQS NIKEGVFEDV YPYRRKKRFK FQRGG