A0KEL3

PR
Gene name
pepQ
Protein name
Xaa-Pro dipeptidase
Names
X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase
Species
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)
KEGG Pathway
aha:AHA_0141
EC number
3.4.13.9: Dipeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0KEL3

Entry ID Method Resolution Chain Position Source
AF-A0KEL3-F1 Predicted AlphaFoldDB

No variants for A0KEL3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0KEL3

No associated diseases with A0KEL3

2 regional properties for A0KEL3

Type Name Position InterPro Accession
domain Peptidase M24 166 - 427 IPR000994
conserved_site Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site 333 - 345 IPR001131

Functions

Description
EC Number 3.4.13.9 Dipeptidases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
metalloexopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
phosphoric triester hydrolase activity Catalysis of the hydrolysis of a phosphoric triester.
proline dipeptidase activity Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal <=> L-proline + a standard alpha amino acid.

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSYSQLFAQ HLDTLQQRTR DILQQQGLSG LAIHSGQTHR IFLDDQDYPF KVNPQFKAWL
70 80 90 100 110 120
PVLDNPHCWL LVDGVNKPVL LFYRPVDFWH KVAELPNAFW VDFFDIRFLT RPEQVADHLP
130 140 150 160 170 180
ANKQEWAYLG GHLEVAELLG LGQPNPEAVL NYLHYHRAYK TAYELECLRD ANRIGVRGHI
190 200 210 220 230 240
AAKDSFMAGA SEFEINLAYM KAVGQGANEA PYGNIVAINR NAAILHYTHL SAQRVPDAER
250 260 270 280 290 300
YSFLIDAGVD VHGYASDITR TWAWRRGEFA DLIAALDAQQ QEIIEEIKPG RRYSELHLQM
310 320 330 340 350 360
HHRLARLLQA TELVDMSVDE MIHTGVTNVF FPHGLGHFLG LQVHDAGGFM QDERGTHLSA
370 380 390 400 410 420
PEQFPYLRCT RVMEVGQVFT IEPGLYFIDS LLEPLRLGEQ GKRVNWNKVE ALRPYGGIRI
430
EDNVVLHANG VENLTRQAGL