A0JYP1
Gene name |
thiE |
Protein name |
Thiamine-phosphate synthase |
Names |
TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase |
Species |
Arthrobacter sp (strain FB24) |
KEGG Pathway |
art:Arth_2782 |
EC number |
2.5.1.3: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A0JYP1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A0JYP1-F1 | Predicted | AlphaFoldDB |
No variants for A0JYP1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A0JYP1 | |||||
No associated diseases with A0JYP1
1 regional properties for A0JYP1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Thiamine phosphate synthase/TenI | 12 - 221 | IPR022998 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.3 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| thiamine-phosphate diphosphorylase activity | Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| thiamine biosynthetic process | The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. |
| thiamine diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTEQALLTDA | RLYLCTDART | DRGDFADFVD | AAYAGGVDII | QLRDKGLEAA | EELELLEVLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TAARRHGRLW | SVNDRADIAS | LSGAPVLHVG | QKDLPLASAR | KFLGGEAVIG | LSTHSHGQID |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AAIAASRGAG | GLDYFCVGPV | WATPTKPGRA | AVGLELVRYA | AEAAGKTTAK | TTGGAAGPTV |
| 190 | 200 | 210 | 220 | 230 | |
| DGPRLPWFAI | GGIDLGNVEQ | VAAAGAERIV | VVRAITEADD | PAAAARSLLA | ALDAGAS |