A0JX57

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Arthrobacter sp (strain FB24)
KEGG Pathway
art:Arth_2247
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0JX57

Entry ID Method Resolution Chain Position Source
AF-A0JX57-F1 Predicted AlphaFoldDB

No variants for A0JX57

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0JX57

No associated diseases with A0JX57

5 regional properties for A0JX57

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 61 - 72 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 442 - 645 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 679 - 802 IPR013155
domain Methionyl/Leucyl tRNA synthetase 60 - 201 IPR015413
domain Leucyl-tRNA synthetase, editing domain 241 - 427 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSVQPETETG TAAVATEGPE EGTYSFAAME AKWPQVWEDL KVFTPVDDGS RERRYVLDMF
70 80 90 100 110 120
PYPSGDLHMG HAEAFAMGDV VARYLRQKGY DVLHPIGWDS FGLPAENAAI KRNAHPSEWT
130 140 150 160 170 180
YANIDTQAAS FKRYAISADW SRRLHTSDPE YYRWTQWLFK RFYERGLAYR KDSPVNWCPK
190 200 210 220 230 240
DQTVLANEQV VNGACERCGT AVTKKSLNQW YFKITDYADR LLDDMDELRG HWPERVLAMQ
250 260 270 280 290 300
KNWIGRSEGA HVNFVIEAAG DKPAKDVTVF TTRPDTLYGA TFFVVAADAP MAVELVTDEH
310 320 330 340 350 360
AAALDAYREQ VKALSEIERQ STEREKTGVF TGRYAVNPLN GEKLPVWAAD YVLADYGTGA
370 380 390 400 410 420
IMAVPAHDQR DLDFARTFDL PVRAVLDTGE DDPAVTGKAT AGEGTLINSG VLDGLPKAEA
430 440 450 460 470 480
IPTAIDMLEK QGTGEKFVNF RLRDWLLSRQ RFWGTPIPII HCPACGEVPV PDDQLPVTLP
490 500 510 520 530 540
ADLRGEDLSP KGTSPLAAAE AWVNVECPNC HGPAKRDTDT MDTFVDSSWY FLRFVSPQYT
550 560 570 580 590 600
EGPFDPKKIN DWMPVGQYVG GVEHAILHLL YARFFTKVIH DLGMIDADEP FSALLNQGQV
610 620 630 640 650 660
LNGGKAMSKS LGNGVDLGEQ LDKYGVDAVR LTMIFASPPE DDVDWADVSP SGSAKFLARA
670 680 690 700 710 720
WRLAQDVSSA PGADAAQGDR ALRSVTHRTI ADAAALLDSN KFNVVVAKLM ELVNATRKTI
730 740 750 760 770 780
DAASGAGGAD PAVREAAEAV AVILSLFAPY TAEDMWNVLG HPASVANAGW PSHDEALLVQ
790 800 810 820 830 840
DTVTAVVQVQ GKVRDRLEVS PEIGEDELRE LALASENVQR ALDGRGIRTV IVRAPKLVNI
VPA