A0JPP4

PR
Gene name
Spesp1
Protein name
Sperm equatorial segment protein 1
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:501010
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

128-223 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0JPP4

Entry ID Method Resolution Chain Position Source
AF-A0JPP4-F1 Predicted AlphaFoldDB

2 variants for A0JPP4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3321340559 169 P>L No EVA
rs3321366508 203 G>A No EVA

No associated diseases with A0JPP4

No regional properties for A0JPP4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A0JPP4

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle, secretory vesicle, acrosome
  • Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase) (By similarity)
  • After acrosome reaction localizes to the equatorial segment region in both noncapacitated and capacitated, acrosome-reacted sperm (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
acrosomal vesicle A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
acrosome reaction The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
fertilization The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
fusion of sperm to egg plasma membrane involved in single fertilization The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.
sperm-egg recognition The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKPVVLVALL WLWPSSFLAY PTATVLPDEE QNLNHYVQIL QNLIMSVPTK EQGFGRKFRS
70 80 90 100 110 120
SRTVDGAEAR SLSSEMLLTP GLVSAQEVTT PETEVMLTSM VEKTTFPSSG FTMESEKRRT
130 140 150 160 170 180
HSKAFWSIQP NNVSIVLHTE EPYIEKEPEP EPELETEEES RRLATEPEPE PESESAPETE
190 200 210 220 230 240
TRQTAESEEE VETSTAQNKV RTGTSRMSTV ITQTTNTQGT PNTVTVKTIN NLDVSTESED
250 260 270 280 290 300
VPQLSGQSEI LNVEDLPGHH SLSTRHENIL RKISNINSQI HQGLLSDHSS PAYKEFIKAS
310 320 330 340 350 360
REHLKRSLAL AAAAEHKLQQ MYGSNVFLDG HTSDPDDDME VIINMLYNSR SKLSDYFTIN
370 380 390 400
HVPSELREKA TVVIAVLKKI LCVDQVEMQS LIRKLLSNNM KILNILNVP