A0JNA8

PR
Gene name
PAXIP1
Protein name
PAX-interacting protein 1
Names
PAX transactivation activation domain-interacting protein
Species
Bos taurus (Bovine)
KEGG Pathway
bta:513213
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

380-517 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0JNA8

Entry ID Method Resolution Chain Position Source
AF-A0JNA8-F1 Predicted AlphaFoldDB

392 variants for A0JNA8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1117579547 87 P>L No EVA
rs439744380 95 S>A No EVA
rs476011660 95 S>L No EVA
rs463008834 109 V>E No EVA
rs454459857 122 T>P No EVA
rs474158697 140 V>I No EVA
rs468213303 148 K>Q No EVA
rs446557415 149 Y>S No EVA
rs479431794 150 E>G No EVA
rs457611281 151 C>G No EVA
rs445896811 151 C>W No EVA
rs481969568 156 A>D No EVA
rs463485308 162 T>N No EVA
rs459758650 179 A>P No EVA
rs441338653 180 L>I No EVA
rs452576843 181 Y>C No EVA
rs470977618 181 Y>H No EVA
rs452576843 181 Y>S No EVA
rs134387848 182 H>P No EVA
rs476860779 182 H>Y No EVA
rs436554787 183 P>A No EVA
rs466412319 183 P>H No EVA
rs446490672 184 R>C No EVA
rs434521029 188 Y>C No EVA
rs463987155 190 E>G No EVA
rs445557584 192 E>Q No EVA
rs481632047 192 E>V No EVA
rs463448407 193 E>V No EVA
rs448387658 194 E>G No EVA
rs801348511 195 E>K No EVA
rs459591559 197 E>G No EVA
rs459591559 197 E>V No EVA
rs471039649 200 G>R No EVA
rs459045912 205 E>G No EVA
rs459045912 205 E>V No EVA
rs476625615 206 P>L No EVA
rs443614076 206 P>T No EVA
rs455122461 207 D>A No EVA
rs436723122 207 D>E No EVA
rs472767317 208 S>P No EVA
rs454356380 209 P>R No EVA
rs136572585 210 N>K No EVA
rs464048804 211 E>G No EVA
rs469635411 213 S>R No EVA
rs436728126 213 S>T No EVA
rs448277949 214 T>A No EVA
rs448277949 214 T>P No EVA
rs481412174 214 T>R No EVA
rs447401483 215 D>E No EVA
rs466030513 215 D>Y No EVA
rs443772218 217 K>N No EVA
rs459007087 217 K>R No EVA
rs483003077 218 S>P No EVA
rs443094029 219 S>G No EVA
rs443094029 219 S>R No EVA
rs472888545 220 P>A No EVA
rs135079889 220 P>L No EVA
rs135079889 220 P>R No EVA
rs438925281 221 A>P No EVA
rs438925281 221 A>S No EVA
rs452066524 222 S>G No EVA
rs469765547 223 S>C No EVA
rs436891496 223 S>P No EVA
rs435997895 224 Q>E No EVA
rs466051787 224 Q>R No EVA
rs447513647 225 E>G No EVA
rs447513647 225 E>V No EVA
rs465197586 226 G>A No EVA
rs477177997 226 G>S No EVA
rs465197586 226 G>V No EVA
rs483166645 227 S>P No EVA
rs461409254 228 P>H No EVA
rs134320807 229 S>A No EVA
rs134320807 229 S>P No EVA
rs460820818 230 G>A No EVA
rs460820818 230 G>E No EVA
rs456621868 231 E>A No EVA
rs444604325 231 E>D No EVA
rs456621868 231 E>G No EVA
rs471789784 231 E>K No EVA
rs471789784 231 E>Q No EVA
rs454560484 236 P>T No EVA
rs454008087 239 S>I No EVA
rs465754383 239 S>R No EVA
rs432288378 251 D>Y No EVA
rs465160439 254 D>G No EVA
rs449857114 256 S>P No EVA
rs460540991 259 K>M No EVA
rs449312113 260 Q>K No EVA
rs479032558 261 E>D No EVA
rs460532245 263 N>S No EVA
rs460532245 263 N>T No EVA
rs445492205 264 L>* No EVA
rs478265883 265 N>T No EVA
rs463098235 266 W>C No EVA
rs444567241 267 T>P No EVA
rs474437353 269 A>E No EVA
rs461029361 270 E>G No EVA
rs442527902 271 V>A No EVA
rs442527902 271 V>G No EVA
rs453773860 272 P>R No EVA
rs472220731 272 P>T No EVA
rs471652311 274 L>R No EVA
rs456444404 275 A>G No EVA
rs467569496 279 R>P No EVA
rs466908000 281 L>R No EVA
rs434112296 281 L>V No EVA
rs463059628 283 P>H No EVA
rs719977966 283 P>S No EVA
rs480837496 285 K>N No EVA
rs462364655 289 L>P No EVA
rs442504806 292 L>M No EVA
rs472227320 292 L>R No EVA
rs460242258 293 C>R No EVA
rs438383041 300 P>H No EVA
rs471413157 306 P>R No EVA
rs456405541 308 V>F No EVA
rs437919516 311 S>C No EVA
rs474013964 315 P>A No EVA
rs455494797 316 G>R No EVA
rs433780162 320 Q>L No EVA
rs466870914 321 G>D No EVA
rs433127019 324 R>S No EVA
rs469244010 326 E>G No EVA
rs451171073 327 V>A No EVA
rs451171073 327 V>G No EVA
rs481031023 331 W>G No EVA
rs468906185 332 S>T No EVA
rs446960937 334 A>V No EVA
rs460205497 337 T>P No EVA
rs438544580 338 L>R No EVA
rs477777940 339 R>G No EVA
rs444316327 342 T>A No EVA
rs455638767 343 N>S No EVA
rs440168349 344 N>H No EVA
rs473040671 344 N>T No EVA
rs451678301 347 I>T No EVA
rs469207320 348 Q>H No EVA
rs433290863 348 Q>P No EVA
rs433290863 348 Q>R No EVA
rs446761147 349 Q>H No EVA
rs457225985 349 Q>K No EVA
rs435584669 350 M>L No EVA
rs468815157 350 M>R No EVA
rs435584669 350 M>V No EVA
rs447157222 351 S>A No EVA
rs447157222 351 S>P No EVA
rs479988427 352 S>G No EVA
rs464792678 352 S>N No EVA
rs464792678 352 S>T No EVA
rs477943154 356 N>H No EVA
rs462651521 356 N>S No EVA
rs480271738 359 H>N No EVA
rs461999788 359 H>P No EVA
rs432173138 362 Q>R No EVA
rs465392705 364 L>V No EVA
rs456643930 365 S>A No EVA
rs477610649 366 A>E No EVA
rs467642142 368 T>A No EVA
rs449489955 371 L>R No EVA
rs445355378 372 E>D No EVA
rs467297325 372 E>G No EVA
rs479065200 372 E>K No EVA
rs876280361 375 V>G No EVA
rs478481433 376 N>T No EVA
rs458564013 377 H>P No EVA
rs443354610 378 S>T No EVA
rs876224807 388 L>P No EVA
rs442457189 394 A>P No EVA
rs876406357 395 P>R No EVA
rs137019869 402 Q>H No EVA
rs135799895 404 I>T No EVA
rs133653764 406 H>P No EVA
rs135939088 407 L>P No EVA
rs876348185 409 P>A No EVA
rs876633203 412 L>R No EVA
rs876424899 431 H>P No EVA
rs876362541 433 F>S No EVA
rs876611749 450 R>P No EVA
rs876571211 456 Q>L No EVA
rs876332954 461 S>P No EVA
rs876404754 473 R>L No EVA
rs876404754 473 R>P No EVA
rs876534250 474 L>R No EVA
rs875998014 475 Q>K No EVA
rs876519383 475 Q>P No EVA
rs876052854 477 M>I No EVA
rs876116685 477 M>R No EVA
rs876247002 480 T>P No EVA
rs876069961 482 T>P No EVA
rs876256756 483 A>P No EVA
rs876468100 490 A>P No EVA
rs876179555 494 Q>H No EVA
rs876404112 495 P>A No EVA
rs876396561 495 P>H No EVA
rs876404112 495 P>S No EVA
rs133171622 499 Q>P No EVA
rs137756482 506 L>P No EVA
rs446305965 535 M>I No EVA
rs473469618 544 W>C No EVA
rs451909188 546 R>S No EVA
rs471677485 547 I>T No EVA
rs444381422 548 I>L No EVA
rs474043029 548 I>S No EVA
rs474043029 548 I>T No EVA
rs444381422 548 I>V No EVA
rs455961967 549 Q>R No EVA
rs434226208 551 H>P No EVA
rs467250402 551 H>Q No EVA
rs434226208 551 H>R No EVA
rs465046123 554 A>P No EVA
rs465046123 554 A>S No EVA
rs482610151 555 V>G No EVA
rs448788349 556 D>A No EVA
rs467341880 556 D>H No EVA
rs478916474 558 T>A No EVA
rs478916474 558 T>P No EVA
rs438565096 560 S>P No EVA
rs438565096 560 S>T No EVA
rs477842880 560 S>W No EVA
rs462879706 566 L>M No EVA
rs444546978 566 L>R No EVA
rs455681401 570 S>R No EVA
rs440415662 572 V>L No EVA
rs473706385 573 S>R No EVA
rs451944100 574 G>R No EVA
rs433346296 576 F>S No EVA
rs457529963 578 Q>* No EVA
rs437653181 578 Q>P No EVA
rs482253986 594 T>K No EVA
rs446037904 594 T>P No EVA
rs482253986 594 T>R No EVA
rs464048065 596 L>M No EVA
rs442340088 596 L>R No EVA
rs481773276 601 L>R No EVA
rs459856121 602 V>E No EVA
rs439152423 607 A>P No EVA
rs456775103 609 H>L No EVA
rs456775103 609 H>P No EVA
rs435437850 610 F>S No EVA
rs452996364 612 V>G No EVA
rs464645778 613 A>G No EVA
rs434605070 613 A>P No EVA
rs446205407 614 F>C No EVA
rs446205407 614 F>S No EVA
rs482215270 616 P>R No EVA
rs470133487 618 G>A No EVA
rs481740004 621 C>R No EVA
rs460073324 622 S>P No EVA
rs441370903 624 H>P No EVA
rs441370903 624 H>R No EVA
rs449131993 626 I>M No EVA
rs478715221 627 S>P No EVA
rs460139343 632 V>G No EVA
rs445016160 644 Y>S No EVA
rs462918302 649 K>N No EVA
rs444408259 652 G>A No EVA
rs474250191 653 Y>S No EVA
rs462449123 654 L>V No EVA
rs440646496 655 C>G No EVA
rs473706282 659 T>P No EVA
rs451894390 660 V>A No EVA
rs433385142 662 I>F No EVA
rs471474389 664 R>G No EVA
rs456205882 664 R>K No EVA
rs431999618 666 P>S No EVA
rs449854707 667 T>N No EVA
rs465265496 667 T>S No EVA
rs449015988 669 L>* No EVA
rs478889182 673 K>Q No EVA
rs460510231 675 K>N No EVA
rs438752772 676 E>D No EVA
rs462961946 677 W>* No EVA
rs444652511 677 W>C No EVA
rs471825967 677 W>G No EVA
rs471825967 677 W>R No EVA
rs455902059 678 R>L No EVA
rs453871997 679 I>M No EVA
rs472272960 679 I>N No EVA
rs472272960 679 I>S No EVA
rs434196786 679 I>V No EVA
rs464881737 681 C>G No EVA
rs464881737 681 C>R No EVA
rs449677920 681 C>W No EVA
rs467531533 682 V>A No EVA
rs467531533 682 V>E No EVA
rs467531533 682 V>G No EVA
rs437858434 682 V>L No EVA
rs437858434 682 V>M No EVA
rs478652067 683 N>D No EVA
rs478652067 683 N>H No EVA
rs460475507 683 N>K No EVA
rs478652067 683 N>Y No EVA
rs478360807 684 A>G No EVA
rs445246778 684 A>P No EVA
rs478360807 684 A>V No EVA
rs462874626 685 Q>P No EVA
rs480957289 686 W>C No EVA
rs444449161 686 W>G No EVA
rs444449161 686 W>R No EVA
rs462482537 687 L>V No EVA
rs440632886 687 L>W No EVA
rs451931191 689 D>G No EVA
rs473544692 689 D>Y No EVA
rs438447378 690 I>N No EVA
rs437627725 692 L>R No EVA
rs455520399 694 N>D No EVA
rs433857299 694 N>K No EVA
rs445044633 695 F>C No EVA
rs466564447 695 F>V No EVA
rs469533531 696 E>A No EVA
rs469533531 696 E>G No EVA
rs478325761 696 E>K No EVA
rs469533531 696 E>V No EVA
rs450783750 697 A>G No EVA
rs462143088 702 Q>E No EVA
rs480123990 702 Q>H No EVA
rs440699900 702 Q>P No EVA
rs134771305 703 Y>D No EVA
rs134771305 703 Y>H No EVA
rs439810151 703 Y>S No EVA
rs456253901 706 Y>D No EVA
rs443988448 708 A>P No EVA
rs443988448 708 A>T No EVA
rs473557651 710 G>R No EVA
rs433820277 713 D>G No EVA
rs455184136 713 D>Y No EVA
rs451375360 719 P>L No EVA
rs433006698 720 Q>E No EVA
rs469449550 720 Q>H No EVA
rs435686484 722 V>G No EVA
rs207554393 724 S>N No EVA
rs458483643 726 L>Q No EVA
rs446192557 727 D>Y No EVA
rs479341883 760 S>C No EVA
rs442845121 760 S>T No EVA
rs471949451 762 K>E No EVA
rs480119199 766 I>N No EVA
rs455055766 802 Y>* No EVA
rs440143500 821 S>T No EVA
rs442969816 841 T>P No EVA
rs472775688 842 P>R No EVA
rs434453958 843 E>G No EVA
rs464186962 844 W>G No EVA
rs437095583 845 L>R No EVA
rs452099876 845 L>V No EVA
rs439042129 846 E>G No EVA
rs481309122 847 E>D No EVA
rs448188227 847 E>G No EVA
rs465915642 848 C>G No EVA
rs447729611 849 F>C No EVA
rs477284185 849 F>L No EVA
rs458798105 850 K>R No EVA
rs458798105 850 K>T No EVA
rs483339576 851 C>F No EVA
rs449955947 851 C>G No EVA
rs483339576 851 C>S No EVA
rs461708606 852 Q>E No EVA
rs443090169 852 Q>H No EVA
rs460718549 853 K>N No EVA
rs472872354 853 K>R No EVA
rs470648972 854 F>L No EVA
rs440965894 854 F>S No EVA
rs452136771 855 V>A No EVA
rs452136771 855 V>G No EVA
rs481220286 856 D>G No EVA
rs459918661 857 E>D No EVA
rs441477572 859 N>K No EVA
rs471231220 860 Y>S No EVA
rs439299016 862 L>R No EVA
rs475455402 864 D>V No EVA
rs456930879 867 A>S No EVA
rs474588535 868 E>Q No EVA
rs434652378 889 K>R No EVA
rs471794727 893 F>I No EVA
rs456489426 896 T>P No EVA
rs468118128 923 S>T No EVA
rs449595481 931 K>M No EVA
rs434212340 931 K>N No EVA
rs467170451 932 Q>* No EVA
rs447318569 933 N>I No EVA
rs385960250 940 V>F No EVA
rs482420556 947 D>A No EVA
rs436975212 952 R>L No EVA
rs462290003 981 Y>* No EVA
rs446885170 983 F>C No EVA
rs479882805 983 F>L No EVA
rs446885170 983 F>S No EVA
rs458037139 984 N>S No EVA
rs458037139 984 N>T No EVA
rs475871048 985 N>C No EVA
rs439878005 985 N>G No EVA

No associated diseases with A0JNA8

6 regional properties for A0JNA8

Type Name Position InterPro Accession
domain BRCT domain 8 - 93 IPR001357-1
domain BRCT domain 94 - 183 IPR001357-2
domain BRCT domain 516 - 609 IPR001357-3
domain BRCT domain 618 - 694 IPR001357-4
domain BRCT domain 773 - 862 IPR001357-5
domain BRCT domain 885 - 974 IPR001357-6

Functions

Description
EC Number
Subcellular Localization
  • Nucleus matrix
  • Chromosome
  • Localizes to DNA damage foci upon ionizing radiation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
MLL3/4 complex A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species.
nuclear matrix The dense fibrillar network lying on the inner side of the nuclear membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
histone H3-K4 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
negative regulation of DNA-binding transcription factor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
positive regulation of transcription initiation by RNA polymerase II Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6ZW49 PAXIP1 PAX-interacting protein 1 Homo sapiens (Human) PR
Q6NZQ4 Paxip1 PAX-interacting protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSGQVPRVPE EMFKEVKYYA VGDLDPQVIQ LLKAGKAKEV SYNALASHII SEDGDNPEVG
70 80 90 100 110 120
EAREVFDLPV VKPSWVILSV QCGALLPVNG FSPESCQIFF GITACLSQVS PEDRSALWAM
130 140 150 160 170 180
LTFHGGGCQL NLNRKCTHLV VPEPKGEKYE CALRRASIKI VTPDWVLDCI SEKTRKDEAL
190 200 210 220 230 240
YHPRLIVYEE EEEEEEEEEG AGNEEPDSPN EGSTDGKSSP ASSQEGSPSG EPPFSPKSSA
250 260 270 280 290 300
EKSKGELMFD DSSDSSPEKQ ERNLNWTPAE VPQLAAAKRR LPPGKEPGLI NLCANVPPVP
310 320 330 340 350 360
GGILPPEVRG SLLAPGQSLQ GPERPEVMAA WSPAMRTLRN ITNNADIQQM SSRPSNVAHI
370 380 390 400 410 420
LQSLSAPTKT LEQQVNHSQQ GPASAVLLGQ VKVAPEPAPA PQPILHLQPQ QLLQLQQQHL
430 440 450 460 470 480
AQQPYPPPPP HPFPPPPAHP HQFPQPPLQR PQPPLQQQQL SHLQQQQLQH LQRLQQMQPT
490 500 510 520 530 540
PTAQLPGPPA QALQPPPPQA QAQPPLFGHD PAVEIPEEGF LLGCVFAIAD YPEQMSDKQL
550 560 570 580 590 600
LATWKRIIQA HGGAVDPTFS SRCTHLLCES QVSGLFAQAM KERKRCITAH WLNTVLKKKK
610 620 630 640 650 660
LVPPHRALHF PVAFPPGGKP CSQHIISVTG FVDNDRDDLK LMAYLAGAKY TGYLCRSNTV
670 680 690 700 710 720
LICREPTGLK YEKAKEWRIP CVNAQWLGDI LLGNFEALRQ TQYGRYTAFG LQDPFAPTPQ
730 740 750 760 770 780
LVLSLLDAWR VPLKVSSELL MGVRLPPKPK QNEVTNVQPS SKRARIEDIP PPTKKLTPEL
790 800 810 820 830 840
TPFVLFTGFE PVQVQQYIKK LYILGGEVAE SAQKCTHLIA SKVTRTVKFL TAISVVKHIV
850 860 870 880 890 900
TPEWLEECFK CQKFVDEQNY LLRDAEAEVL FSFSLEESLR RAHASPLFKA KYFYITPGIC
910 920 930 940 950 960
PSLSTMKAIV ECAGGKVLSR QPSFRKLMEH KQNKSLSEIV LISCENDLHL CREYFARGID
970 980
VHNAEFVLTG VLTQTLDYES YKFN