A0JMR6
Gene name |
mysm1 |
Protein name |
Histone H2A deubiquitinase MYSM1 |
Names |
2A-DUB, Myb-like, SWIRM and MPN domain-containing protein 1 |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:779416 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A0JMR6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A0JMR6-F1 | Predicted | AlphaFoldDB |
No variants for A0JMR6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A0JMR6 | |||||
No associated diseases with A0JMR6
6 regional properties for A0JMR6
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type deubiquitinase activity | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| metal ion binding | Binding to a metal ion. |
| metal-dependent deubiquitinase activity | An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| transcription coactivator activity | A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| monoubiquitinated histone H2A deubiquitination | The removal of the ubiquitin group from a monoubiquitinated histone H2A protein. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEEAADVDI | DIEGDINESS | KSIYDSLNTG | FAPEHYIESA | WQNEEGLAPW | ALDSSISEEN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| REAIKKMLLE | EEYYLSNKPL | AVKFWSDSQE | GEKQCIKRVR | SPAKASSSPV | KWTKEEKNLF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EQGLATFGRR | WTSIARLIGS | RSVLQVKNYA | RHYFKNKCKL | EGFVKEEAKI | GSLQIPNLQD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YENEPDITDE | PTTFRGRADP | NLNAIKIEKL | SDDEEIDITD | EVDELLSNKT | NLDTIIIAKT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DKVKETKVET | EVQQKSHSTT | EHSQTDIPKL | VLQQTETECL | DSVNPLTCIT | SPKWTLSPQQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CEEDDYDQPD | VQDCLQEKCL | SPHAEDLTVL | CENENDSQDE | DDEIKPPDQE | LEIDRNFILD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EEKQAIPEFF | EGRQAKTPDR | YLRIRNYILD | QWENCKPKYL | NKTSVRPGLK | NCGDVNCIGR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IHTYLELIGA | INFGCEQAIY | NRPRPVDKTK | CKEGKDTLEA | YKLAHRLQSM | RTRKRRVRDP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WGNWCDAKDL | EGQTYEHLSA | EELARRHEDK | IKSYKYSKGT | RQVRSSFDPF | QLIPCSAFSE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EKKAPFQVKV | SCEAMLVLDL | HAHVSMAEVI | GLLGGRYTES | ESVVEICAVE | PCNSLSTGLQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| CEMDPVSQTQ | ASEALASRGY | SVIGWYHSHP | AFDPNPSIRD | IDTQAKYQNY | FSRGGAKFLG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MIISPYNRRN | PHPQSQVACL | IISDELSNDG | SYRIPYKFEI | EYMQGEPQWE | LVFAKTRWII |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EKYRSSHSSV | SMDKRFRHDS | ELTCLQKLLM | CMKKTLGNTA | CPLITEEFLH | RIEEYFRTSY |
| 790 | 800 | 810 | |||
| KKESNYQIED | NDPCKQHSDT | TFTMDSFQDY | EPNGRPSL |