A0A0G2JUG7

PR
Gene name
Iqsec1 (Brag2)
Protein name
IQ motif and SEC7 domain-containing protein 1
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

134-163 (IQ motif) SS

Target domain

516-863 (Sec7-PH domains)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0A0G2JUG7

Entry ID Method Resolution Chain Position Source
AF-A0A0G2JUG7-F1 Predicted AlphaFoldDB

No variants for A0A0G2JUG7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0A0G2JUG7

No associated diseases with A0A0G2JUG7

14 regional properties for A0A0G2JUG7

Type Name Position InterPro Accession
domain Leucine-rich repeat N-terminal domain 31 - 63 IPR000372
domain Cysteine-rich flanking region, C-terminal 160 - 208 IPR000483
domain Protein kinase domain 538 - 814 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 539 - 809 IPR001245
repeat Leucine-rich repeat 104 - 160 IPR001611
conserved_site Tyrosine-protein kinase, receptor class II, conserved site 703 - 711 IPR002011
domain Immunoglobulin subtype 216 - 302 IPR003599
domain Immunoglobulin-like domain 210 - 300 IPR007110
active_site Tyrosine-protein kinase, active site 675 - 687 IPR008266
domain Immunoglobulin I-set 323 - 391 IPR013098
domain Immunoglobulin-like beta-sandwich domain 218 - 296 IPR013151
binding_site Protein kinase, ATP binding site 544 - 572 IPR017441
domain Tyrosine-protein kinase, catalytic domain 538 - 810 IPR020635
domain Growth factor receptor NTRK, leucine rich repeat C-terminal 163 - 208 IPR031635

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane; Lipid-anchor; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
postsynapse The part of a synapse that is part of the post-synaptic cell.
postsynaptic density, intracellular component A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
Schaffer collateral - CA1 synapse A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
synaptic vesicle A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.

3 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
lipid binding Binding to a lipid.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

8 GO annotations of biological process

Name Definition
actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
dendritic spine development The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
positive regulation of focal adhesion disassembly Any process that activates or increases the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components.
positive regulation of keratinocyte migration Any process that activates or increases the frequency, rate or extent of keratinocyte migration.
positive regulation of synapse assembly Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
postsynaptic modulation of chemical synaptic transmission Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.
regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction.
regulation of postsynaptic neurotransmitter receptor internalization Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5JU85 IQSEC2 IQ motif and SEC7 domain-containing protein 2 Homo sapiens (Human) EV
Q9UPP2 IQSEC3 IQ motif and SEC7 domain-containing protein 3 Homo sapiens (Human) SS
Q6DN90 IQSEC1 IQ motif and SEC7 domain-containing protein 1 Homo sapiens (Human) EV
Q3TES0 Iqsec3 IQ motif and SEC7 domain-containing protein 3 Mus musculus (Mouse) SS
Q5DU25 Iqsec2 IQ motif and SEC7 domain-containing protein 2 Mus musculus (Mouse) SS
Q8R0S2 Iqsec1 IQ motif and SEC7 domain-containing protein 1 Mus musculus (Mouse) SS
D4A631 Arfgef1 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 Rattus norvegicus (Rat) PR
Q7TSU1 Arfgef2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 Rattus norvegicus (Rat) PR
Q76M68 Iqsec3 IQ motif and SEC7 domain-containing protein 3 Rattus norvegicus (Rat) SS
P63035 Cyth2 Cytohesin-2 Rattus norvegicus (Rat) SS
P97696 Cyth3 Cytohesin-3 Rattus norvegicus (Rat) SS
P97694 Cyth1 Cytohesin-1 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MGHCYSRNIS TVDDDDEIPS ATAQLPHRSH QNHHQTSSSS SIPQSPATSE VNPYNISPFQ
70 80 90 100 110 120
SPLPAGVAPS PARTPGRKFK WPFPPPSPAK PIMAALRRRR GTAPHPRDGP IPEDSEAGGS
130 140 150 160 170 180
GGGIGERLDK NFGFAKNFEG KYELGREVGR GHFGHTCWAK AKKGKIKGQT VAVKIISKSK
190 200 210 220 230 240
MTSALSIEDV RREVKLLKAL SGHSHMVKFY DVFEDSDNVF VVMELCEGGE LLDSILARGG
250 260 270 280 290 300
RYPEAEAKRI LVQILSATAF FHLQGVVHRD LKPENFLFTS KNEDAVLKVI DFGLSDYARF
310 320 330 340 350 360
DQRLNDVVGS AYYVAPEVLH RSYSTEADIW SIGVISYILL CGSRPFYGRT ESAIFRCVLR
370 380 390 400 410 420
ANPNFDDLPW PSISPIAKDF VKRLLNKDHR KRMTAAQALA HPWLRDENPG LLLDFSIYKL
430 440 450 460 470 480
VKSYIRASPF RRAALKSLSK AIPEEELVFL KAQFMLLEPE DGGLHLHNFT TALTRYATDA
490 500 510 520 530 540
MIESRLPDIL NMMQPLAHKK LDFEEFCAAS VSVYQLEALE EWEQIATVAF EHFESEGSRA
550 560 570 580 590
ISVQELAEEM SLGPNAYPLL KDWIRSLDGK LNFLGYAKFL HGVTVRSSSS RPMR