AiPD: Autoinhibited Protein Database

A0A089XS13

Gene name	glnR
Protein name	Glutamine synthetase (HTH-type transcriptional regulator GlnR) (MerR family transcriptional regulator)
Names
Species	Lactococcus lactis
KEGG Pathway	llj:LG36_2137
EC number
Protein Class

Descriptions

GlnR is a repressor that regulates gene expression in response to changes in nitrogen availability. The C-terminal autoinhibitory region impedes the dimerization of GlnR and consequently prevents the binding of GlnR N-terminal domain to DNA.

Autoinhibitory domains (AIDs)

88-114 (C-terminal autoinhibitory region) SS

Target domain	12-81 (DNA-binding domain)
Relief mechanism	Partner binding
Assay

AID

88-114 (C-terminal autoinhibitory region)

Target domain

12-81 (DNA-binding domain)

Relief mechanism

Partner binding (Structural rearrangement of C-terminal region by FBI-GS)

Assay

Accessory elements

No accessory elements

References

Wray LV Jr et al. (2008) "Bacillus subtilis GlnR contains an autoinhibitory C-terminal domain required for the interaction with glutamine synthetase", Molecular microbiology, 68, 277-85

Autoinhibited structure

Activated structure

0 structures for A0A089XS13

Entry ID	Method	Resolution	Chain	Position	Source

No variants for A0A089XS13

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for A0A089XS13

No associated diseases with A0A089XS13

1 regional properties for A0A089XS13

Type	Name	Position	InterPro Accession
domain	MerR-type HTH domain	12 - 81	IPR000551

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

1 GO annotations of biological process

Name	Definition
regulation of transcription, DNA-templated	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MKERELRRSM	AVLPIGTVMK	LTDLSARQIR	YYEEQELIFP	ERSDGNRRMY	SLNDIDALFD
70	80	90	100	110	120
IADLLQEGNN	IADIKEIYAK	RDAKKAQTLS	IGEVHHALER	EFAQQGRFGT	PDPTHFTQPR

M